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. 2019 Sep 26;39(11):2338–2352. doi: 10.1161/ATVBAHA.119.313246

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© 2019 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 3. — Distinct lipoprotein profile with larger and regular LDL (low-density lipoprotein) associated with coronary atherosclerosis disease severity at T1. A, Representative fast-protein liquid chromatography (FPLC) profiles of one advanced-diseased pig (AD) and one mildly diseased pig. Both the cholesterol levels (black line) and the triglyceride levels (gray line) are indicated. Larger LDL has the same size as VLDL (very-low–density lipoproteins). B, Sequential separation of lipoproteins using density-gradient ultracentrifuge (DGUC) and FPLC (graph of one example AD pig). Lipoproteins were separated on density using DGUC. Subsequently, the pooled LDL fractions were subjected to FPLC revealing the presence of regular LDL and larger LDL. HDL indicates high-density lipoprotein.