Appendix 1—table 1. Parameter values used to generate the optimized PK curves for all 17 volunteers.
The units of the model parameters are given in the parentheses. The optimized PK curves are shown in Figure 6—figure supplement 1.
| PK parameter (unit) | kT(h-1) | qc(L/h) | Vc(L) | q1(L/h) | V1(L) | q2(L/h) | v2(L) |
|---|---|---|---|---|---|---|---|
| Volunteer 101 | 1/2.43 | 53.7 | 831 | 2240 | 3958 | 118 | 17177 |
| Volunteer 102 | 1/2.32 | 123.4 | 582 | 849 | 3985 | 163 | 10355 |
| Volunteer 103 | 1/3.07 | 61.3 | 756 | 2686 | 3910 | 127 | 14346 |
| Volunteer 104 | 1/2.32 | 134.7 | 488 | 746 | 3986 | 190 | 15007 |
| Volunteer 105 | 1/3.25 | 160 | 1342 | 5034 | 3986 | 190 | 17546 |
| Volunteer 106 | 1/2.40 | 60.7 | 667 | 2992 | 3043 | 123 | 16374 |
| Volunteer 201 | 1/2.32 | 160 | 469 | 746 | 3986 | 190 | 15557 |
| Volunteer 202 | 1/2.79 | 71.4 | 804 | 2020 | 3010 | 149 | 13300 |
| Volunteer 203 | 1/2.32 | 141.9 | 1243 | 803 | 3973 | 190 | 11825 |
| Volunteer 204 | 1/2.32 | 63.3 | 895 | 2169 | 3327 | 165 | 16205 |
| Volunteer 301 | 1/2.79 | 61.4 | 804 | 2020 | 3010 | 149 | 13300 |
| Volunteer 302 | 1/2.79 | 81.4 | 804 | 2020 | 3010 | 149 | 13300 |
| Volunteer 303 | 1/2.45 | 159.4 | 1332 | 779 | 3970 | 190 | 17355 |
| Volunteer 304 | 1/2.48 | 158.9 | 1339 | 762 | 3981 | 190 | 17290 |
| Volunteer 305 | 1/2.53 | 120.9 | 1152 | 1905 | 2979 | 123 | 13896 |
| Volunteer 306 | 1/2.32 | 158.8 | 870 | 761 | 3983 | 190 | 17488 |
| Volunteer 307 | 1/2.79 | 51.4 | 804 | 2020 | 3010 | 149 | 13300 |