Table 2. Details of the gametocyte dynamics model parameters.

The table includes the unit, description and prior distribution for each model parameter. For the uniform prior distributions (U), the lower bounds are non-negative based on the definitions of the model parameters and the upper bounds for the prior distributions were chosen to be sufficiently wide in order to accommodate all biologically plausible values from the literature (Zaloumis et al., 2012). We assumed parasites younger than 25h are circulating and thus fix $a_s$ to be 25h. For 3D7 strain, the asexual replication cycle is approximately 39–45h (based on in vitro estimates [Duffy and Avery, 2017] and personal communication [JS McCarthy, personal communication, May 2019]) and we fix $a_L$ to be 42h.

Parameter	Unit	Description	Prior distribution
${\displaystyle P_{init}}$	parasites/mL	inoculation size	U(0, 10)
${\displaystyle \mu }$	h	mean of the initial parasite age distribution	U(0, 35)
${\displaystyle \sigma }$	h	SD of the initial parasite age distribution	U(0, 20)
${\displaystyle r_P}$	(unitless)	parasite replication rate	U(0, 100)
${\displaystyle k_{max}}$	h−1	maximum rate of parasite killing by PQP	U(0, 1)
${\displaystyle E{C}_{50}}$	ng/mL	half-maximum effective PQP concentration	U(1, 100)
${\displaystyle \gamma }$	(unitless)	Hill coefficient for PQP	U(0, 20)
${\displaystyle f}$	(unitless)	the fraction of parasites entering sexual development per asexual replication cycle	U(0, 1)
${\displaystyle {\delta }_P}$	h−1	death rate of asexual and sexual parasites	U(0, 0.2)
${\displaystyle m}$	h−1	maturation rate of gametocytes	U(0, 0.1)
${\displaystyle {\delta }_G}$	h−1	death rate of sequestered gametocytes	U(0, 0.1)
${\displaystyle {\delta }_{Gm}}$	h−1	death rate of circulating gametocytes	U(0, 0.1)
${\displaystyle a_s}$	h	sequestration age of asexual parasites	fixed to be 25
${\displaystyle a_L}$	h	length of life cycle of asexual parasites	fixed to be 42

SD: standard deviation; h: hour.