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. 2019 Sep 23;129(11):4629–4642. doi: 10.1172/JCI126714

Figure 4. HIV-1 cell-associated RNA sequences obtained from single cells in peripheral blood and in lymph nodes during ART.

Figure 4

Neighbor joining trees were constructed from single-genome P6-PR-RT proviral DNA and cell-associated HIV-1 RNA sequences obtained from paired PBMCs and LNMCs sampled during continuous viral suppression on ART. Black and blue triangles indicate HIV-1 DNA sequences from PBMCs and LNMCs, respectively; solid squares and hollow squares indicate HIV-1 RNA sequences from PBMCs and LNMCs, respectively. Squares with no genetic difference of the same color indicate sequences that are assumed to be from the expression of single infected cells. Black arrows indicate sequences detected in probable clones in both the samples. The yellow arrow indicates a sequence detected in rebound plasma viremia. Trees are rooted on the subtype B consensus sequence. Results from a total of 8 samples (4 samples each from 2 patients) are represented in this figure.