Figure 8. Focusing of the humoral response toward bNAbs and expression of multiple bNAb types was associated with greater plasma neutralizing breadth.

(A) Neutralizing breadth of plasma samples from subjects in the persistence or clearance group (no. out of 19 HCVpp neutralized > 50% by a 1:100 dilution of plasma). (B) Correlation between total proportion of each plasma response attributed to bNAbs and neutralizing breadth of that plasma sample. P and r values were calculated by Pearson’s method. (C) Relationship between the number of bNAb types expressed by each plasma sample and neutralizing breadth of that sample. **P < 0.01 for the trend by 1-way ANOVA.