Figure 7. Cancer cells with naturally acquired SF3B1 mutation show vulnerability to serine and glycine starvation in vivo.

(A) HNT34 cells were subcutaneously injected into NSG mice given +SG or –SG diets, and tumor volume measurements were obtained starting at 5 weeks, with 10 biologic replicates in each group. (B) MUTZ3 cells were subcutaneously injected into NSGS mice given +SG or –SG diets and tumors were excised from euthanized animals and measured at week 4, with 4 biologic replicates in each group. ***P < 0.001, **P < 0.01, *P < 0.05 for t tests between dietary groups.