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. 2019 Sep 23;129(11):4657–4670. doi: 10.1172/JCI128840

Figure 5. Annexin A6 enhanced membrane repair capacity of healthy and dystrophic myofibers in vitro.

Figure 5

(A) Plasmid expression of annexin A6 in wild-type (WT) myofibers reduced FM 4-64 dye uptake, a marker of membrane damage, after laser-induced injury as compared with control myofibers. (B) Wild-type myofibers injured in the presence of extracellular recombinant annexin A6 (rANXA6) had significantly less FM 4-64 dye uptake compared with control myofibers. (C) Dystrophic (Dys) myofibers injured in the presence of rANXA6 had significantly less FM 4-64 dye uptake than control myofibers. Scale bars: 5 μm. Data are expressed as mean ± SEM. Differences were assessed by 2-tailed t test. *P < 0.05 (n = 10 myofibers from n = 3 mice per condition).