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. 2019 Oct 14;129(11):4951–4961. doi: 10.1172/JCI126108

Figure 3. YM58483 pretreatment attenuates renal ischemia reperfusion injury.

Figure 3

(A) Assessment of renal function by plasma creatinine 24 hours after I/R in Sprague-Dawley rats pretreated with YM-58483 or vehicle. Values for sham rats were 0.4 ± 0.1 mg/dL and are not shown on graph. (B) Kim-1 mRNA levels from total kidney RNA 24 hours after sham or I/R are shown. ND, not detectable. Total kidney-derived CD4+ and CD8+ cells are shown in C and D, respectively; total B cells (RT1B+) and dendritic/macrophage cells (DC/Mᶲ; CD11b/c+) are shown in E and F, respectively. The total number of IL-17+, CD4+/IL-17+ and CD8+/IL-17+ cells are shown in G, H, and I respectively. CD4+/IFN-γ+ cells are shown in J. Data are mean ± SE; n = 11 rats/group in A and n = 7–8 rats in B–J. *P < 0.05 I/R vehicle versus sham; †P < 0.05 vehicle versus YM58483 by 1-way ANOVA and Tukey’s post hoc test.