Figure 4. YM58483 attenuates inflammation and progressive renal damage following I/R and exposure to high-salt diet.

Shown are levels of renal CD4⁺ (A), CD8⁺ T cells (B), IL-17⁺ expressing cells (C), and CD4⁺/IL-17⁺ cells (D). Levels of B cells (E) and dendritic cells/Mᶲ (F) are shown. (G) Creatinine clearance from 24-hour urine collections at day 62–63 and (H) urinary albumin/creatinine ratio. (I) Representative picrosirius red–stained sections through renal outer medulla from sham, I/R vehicle, or I/R plus YM58483-treated rats. (J) Quantification of stained area. Data are mean ± SE; n = 5–6 rats/group. *P < 0.05 I/R vehicle vs sham; ^†P < 0.05 vehicle versus YM58483 by 1-way ANOVA and Tukey’s post hoc test.