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. 2019 Sep 23;129(11):4643–4656. doi: 10.1172/JCI127286

Figure 3. A lack of peritoneal macrophages results in more neutrophil recruitment and less dissemination of S. aureus to the kidneys.

Figure 3

GATA6-KOmye mice or littermate controls were infected i.v. (A–H) or i.p. (I and J) for indicated time points with 5 × 107 S. aureus Newman strain. (A–E and J) Organs were collected and the CFU determined; the geometric mean is shown. n = 5–10 from at least 2 independent experiments, Mann-Whitney test, *P < 0.05. (F) S. aureus cell localization inside the peritoneal cavity determined by flow cytometry, mean percentage. n = 5 (WT) or 6 (GATA6-KOmye). (G and I) Neutrophil numbers in the peritoneal cavity assessed by flow cytometry. n = 5–6, mean ± SEM, unpaired t test, **P < 0.01. (H) Body weight loss, n = 6–9 from 3 independent experiments, mean ± SEM, unpaired t test, *P < 0.05.