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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Hepatology. 2019 Jun 21;70(5):1506–1520. doi: 10.1002/hep.30699

Figure 4. The antiviral effect of the IFITMs is independent of virus infectivity.

Figure 4

Huh7.5.1 cells were transduced to express IFITM proteins and infected with HCVpp bearing the envelope proteins of the indicated variants. (A) Shown are three individual datasets of the experiments that are featured in figure 2A. (B) Correlation of relative infectivity (highest infectivity set to 1) and relative IFITM-sensitivity (highest IFITM-sensitivity set to 1, lowest to 0). Each dot represents one of the escape variants shown in Figure 3C and 3D. Shown are the results of one representative experiment performed in triplicate (n=9).