Table 2:

Stratified Odds Ratios for Alcohol Consumption and CRC by Key Covariates¹

		Alcohol consumption
		Light/moderate (1.1–28 g/day) vs non/occasional				Heavy (28.1–42 g/day) vs non/occasional				Very heavy (>42 g/day) vs non/occasional				Interaction p-value
Meta Analyses	N	OR2	95% CI		p-value	OR2	95% CI		p-value	OR2	95% CI		p-value
Overall	30,078	0.92	0.88	0.98	0.005	1.11	0.99	1.24	0.077	1.25	1.11	1.40	<0.001
Study Design
Case Control	11,317	0.91	0.83	1.00	0.056	1.11	0.92	1.34	0.29	1.20	1.01	1.42	0.04
Cohort	18,761	0.93	0.87	1.00	0.04	1.11	0.96	1.28	0.157	1.29	1.11	1.51	0.001
Sex														0.204
Female	15,067	0.88	0.82	0.95	0.001	1.12	0.91	1.37	0.289	1.01	0.77	1.32	0.967
Male	15,011	0.96	0.88	1.05	0.351	1.09	0.94	1.26	0.243	1.32	1.15	1.51	<0.001
BMI														0.736
Normal or Underweight	11,254	0.88	0.80	0.96	0.005	1.11	0.91	1.34	0.301	1.13	0.91	1.40	0.275
Overweight	12,876	0.89	0.81	0.97	0.007	1.06	0.89	1.26	0.18	1.25	1.05	1.49	0.011
Obese	5,928	1.07	0.93	1.22	0.366	1.04	0.76	1.43	0.812	1.38	1.04	1.83	0.025
Cancer Site														0.093
Proximal	5,562	0.94	0.87	1.01	0.094	1.05	0.90	1.23	0.511	1.13	0.96	1.32	0.145
Distal	4,000	0.91	0.83	0.99	0.026	1.19	1.01	1.41	0.004	1.39	1.18	1.64	<0.001
Rectal	3,109	0.91	0.82	1.01	0.063	1.17	0.97	1.41	0.099	1.46	1.22	1.76	<0.001

¹See footnotes in Figure 2 for adjustment factors

²All estimates calculated by fixed effect meta-analysis