Table 3.
Survival analysis comparing groups by primary site of distant metastasis for cancer-specific survival among included stage III primary testicular germ cell tumor patients. Harrell’s C 0.713. Surveillance, Epidemiology, and End Results Program 2010–2015.
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||||
|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | ||||||
| Univariable | Multivariable1 | ||||||||
| Age | 1.03 | 1.02 | 1.04 | <0.01 | 1.03 | 1.01 | 1.04 | <0.01 | |
| Histology | NSGCT | REF | - | - | - | REF | - | - | - |
| Seminoma | 0.92 | 0.61 | 1.38 | 0.68 | 0.65 | 0.42 | 1.02 | 0.06 | |
| Metastasis | Lung Only | REF | - | - | - | REF | - | - | - |
| Liver (+/− Lung) | 2.40 | 1.65 | 3.48 | 0.01 | 2.29 | 1.56 | 3.35 | <0.01 | |
| Bone (+/− Lung) | 2.10 | 1.21 | 3.64 | <0.01 | 1.97 | 1.11 | 3.50 | 0.02 | |
| Brain (+/− Lung) | 3.21 | 1.99 | 5.18 | <0.01 | 3.24 | 1.98 | 5.28 | <0.01 | |
| Multiple Nonpulmonary Sites | 4.94 | 3.13 | 7.79 | <0.01 | 4.27 | 2.60 | 7.00 | <0.01 | |
1
Multivariable Cox-proportional hazards models also adjusted for race, diagnosis year, laterality, and presence of lymphovascular invasion.
HR = hazard ratio, 95% CI = 95% confidence interval