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Hypertrophic cartilage template induced mineralization: Extracellular calcium deposition on PLGA and hybrid matrices before (A) and after homing (B). Both scaffolds and fresh hBMSCs are added to ultra-low attachment plates and cultured in basal media for 21 days to evaluate cell homing and subsequent extracellular calcium deposition (n=3, p<0.05). Representative images of alizarin red stained PLGA (left) and hybrid (right) matrices before (C) and after (D) fresh hBMSCs seeding.
