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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Acta Neuropathol. 2019 Apr 8;139(4):625–641. doi: 10.1007/s00401-019-02002-2

Figure 6. SEGA-like astrocytoma.

Figure 6.

Neoplasms resembling subependymal giant cell astrocytomas (SEGA) typical of tuberous sclerosis occur in a subset of individuals with NF1, although they tend to be hemispheric (a, b,c). As SEGA, they express glial markers (GFAP, d; OLIG2, e) and neuronal markers (synaptophysin, f). SEGA-like astrocytoma in NF1 patient (g) with intact ATRX expression (h) but large telomere foci (red) colocalizing with Promyelocytic bodies (green)(arrow) consistent with alternative lengthening of telomeres (i).