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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Acta Neuropathol. 2019 Apr 8;139(4):625–641. doi: 10.1007/s00401-019-02002-2

Figure 7. Sporadic pilocytic astrocytoma with anaplasia and NF1 pathogenic gene variant.

Figure 7.

Axial T1-weighted MRI demonstrating a thalamic mass with heterogeneous enhancement (arrow), as well as intraventricular nodules consistent with subependymal spread (arrowheads) (a). First biopsy demonstrated a pilocytic astrocytoma (b). Recurrence in the absence of treatment showed a cellular glial neoplasm with brisk mitotic activity consistent with anaplastic progression (c). Next generation sequencing demonstrated a somatic truncating NF1 p.R816* variant with a variant allele frequency (VAF) of 38.5 (c). No other significant gene sequencing variants were identified.