Table 2: Study 3 – Pareto-optimal results for tTIS and tACS of three target regions.

From a large set of current patterns, Pareto boundaries were constructed that maximize field strength in a small target region (E_ROI) while minimizing the stimulated brain volume (Vol_0.25) (Fig. 10). The table lists the maximum achievable E_ROI on this boundary (filled circles in Fig. 10). Percentages listed indicate the percentage of stimulated brain volume for the current pattern that minimizes Vol_0.25 with E_ROI > 0.25 V/m (open circles in Fig. 10). For the hippocampus target not all stimulation types reached this value, so E_ROI > 0.17 was used. The value of 0.00% in the table indicates a percentage lower than 0.005.

Target	$E_{\mathrm{TI}}^{\mathrm{free}}$	$E_{\mathrm{AC}}^{\mathrm{free}}$	$E_{\mathrm{TI}}^{\mathrm{pref}}$	$E_{\mathrm{AC}}^{\mathrm{pref}}$
Left hippocampus
Maximum EROI (V/m)	0.24	0.25	0.17	0.18
Vol0.25 GM (%)	0.00	0.05	0.70	1.62
Vol0.25 WM (%)	0.69	2.81	2.67	5.09
Right pallidum
Maximum EROI (V/m)	0.37	0.37	0.27	0.27
Vol0.25 GM (%)	0.09	2.16	0.67	2.06
Vol0.25 WM (%)	3.64	9.89	3.02	6.11
Left motor cortex
Maximum EROI (V/m)	0.56	0.60	0.26	0.31
Vol0.25 GM (%)	0.05	0.05	0.57	0.60
Vol0.25 WM (%)	0.18	0.10	1.96	0.96