Table 1.

Elements of the PICOS question defined for this review

	Inclusion	Exclusion
Population	Age 18 years and over Infected with hepatitis C	Age less than 18 years Co-infection with Hepatitis B virus Co-infection with HIV
Intervention	Provision of hepatitis C treatment in any primary care and community environments Treatment using any direct acting antiviral therapy Care provider could be any health care provider	Hepatitis C treatment in prison populations Treatment with ribavirin / interferon regimes as the primary intervention
Comparison	Care in any hospital or secondary care environment or no comparison group
Outcome	Treatment uptake, treatment completion and SVR outcomes
Study design	Observational studies, retrospective or prospective cohort studies, randomised trials; conference abstracts; qualitative and mixed methods studies	Case studies; systematic reviews