Table 1.
Description of participants with current asthma at baseline (EGEA2) according to change in current asthma between EGEA2 to EGEA3
| All participants | Participants with remittent asthma | Participants with persistent asthma | P-value | |
|---|---|---|---|---|
| N | 204 | 43 | 161 | |
| Age (years), mean ± SD | 39.3 ± 16.9 | 36.7 ± 15.3 | 40.0 ± 17.3 | 0.26 |
| Male, n (%) | 99 (48.5) | 16 (37.2) | 83 (51.6) | 0.09 |
| Smoking status, n (%) | ||||
| Never-smoker | 109 (53.4) | 22 (51.2) | 87 (54.0) | 0.52 |
| Ex-smoker | 46 (22.6) | 8 (18.6) | 38 (23.6) | |
| Current smoker | 49 (24.0) | 13 (30.2) | 36 (22.4) | |
| BMI (kg/m2), mean ± SD | n = 203 | 23.4 ± 3.99 | n = 160 | 0.40 |
| 23.8 ± 3.84 | 23.9 ± 3.81 | |||
| Socioprofessional category, n (%) | ||||
| Unemployed | 32 (15.7) | 5 (11.6) | 27 (16.8) | 0.37 |
| Manager | 64 (31.4) | 12 (27.9) | 52 (32.3) | |
| Technician | 88 (43.1) | 19 (44.2) | 69 (42.8) | |
| Manual worker | 20 (9.8) | 7 (16.3) | 13 (8.1) | |
| Asthma onset years, mean ± SD | N = 195 | N = 39 | N = 156 | 0.40 |
| 14.8 ± 14.7 | 16.6 ± 14.6 | 14.4 ± 14.7 | ||
| Poor controlled asthmaa, n (%) | N = 190 | N = 38 | N = 152 | 0.007 |
| 102 (53.7) | 13 (34.2) | 89 (58.6) | ||
| Use of inhaled corticosteroids, n (%) | N = 200 | N = 41 | N = 159 | 0.009 |
| 132 (66.0) | 20 (48.8) | 112 (70.4) | ||
| Symptom score of asthmab, n (%) | N = 199 | N = 40 | N = 159 | |
| 0 | 20 (10.0) | 9 (22.5) | 11 (6.9) | 0.005 |
| 1–2 | 30 (15.1) | 8 (20.0) | 22 (13.8) | |
| >2 | 149 (74.9) | 23 (57.5) | 126 (79.3) | |
| Plasma FlOPs levels (RFU/mL), GM (q1-q3) | 92.0 (79.5–104.7) | 85.6 (76.0–96.5) | 93.8 (79.9–104.8) | 0.02 |
| Residence time (years), mean ± SD | 11.7 ± 10.2 (0–42) | 10.3 ± 8.90 (0–31) | 12.1 ± 10.5 (0–42) | 0.31 |
| Air pollutant levels and traffic metricsc, mean ± SD | ||||
| NO2 | 27.9 ± 13.9 | 29.7 ± 15.3 | 27.4 ± 13.5 | 0.34 |
| NOX | 49.7 ± 32.7 | 53.2 ± 38.4 | 48.8 ± 31.0 | 0.44 |
| PM10 | 25.0 ± 4.07 | 25.1 ± 3.71 | 24.9 ± 4.18 | 0.88 |
| PM2.5 | 15.0 ± 2.04 | 15.5 ± 1.96 | 14.9 ± 2.05 | 0.20 |
| Traffic load | 1,755,353 ± 4,718,630 | 1,672,062 ± 4,007,561 | 1,777,599 ± 4,902,148 | 0.90 |
| Traffic intensity | 7307 ± 13,109 | 7027 ± 11,360 | 7382 ± 13,569 | 0.87 |
| O3 | 43.9 ± 4.62 | 43.1 ± 4.08 | 44.2 ± 4.74 | 0.15 |
| O3-summer | 65.4 ± 6.20 | 64.7 ± 6.41 | 65.6 ± 6.14 | 0.38 |
SD standard deviation, BMI body mass index, FlOPs fluorescent oxidation products, GM geometric mean; q1-q3: 25th and 75th percentiles of the GM
aDefined according to GINA 2015 guidelines and from participants with partly controlled asthma or uncontrolled asthma (see Additional file 1)
bMore details in Additional file 1
cPollutant levels in μg/m3, traffic load in vehicles/day x meters, and traffic intensity in vehicles/day