Table 3.
Clinical characteristics affecting overall survival of patients with ALS
| Clinical characteristic | Total participants (n = 45) | Survival time from onset (mo), mean (95% CI) | Log rank p value | Spinal onset (n = 24) | Survival time from onset (mo), mean (95% CI) | Log rank p value | Bulbar onset (n = 21) | Survival time from onset (mo), mean (95% CI) | Log rank p value |
|---|---|---|---|---|---|---|---|---|---|
| Age at onset, n (%) | |||||||||
| < 60 years, n (%) | 23 (51.11) | 72.30 (57.84–86.77) | 0.3841 | 15 (62.50) | 77.33 (58.71–95.95) | 0.8671 | 8 (38.09) | 62.88 (35.13–90.62) | 0.3895 |
| > 60 years, n (%) | 22 (48.88) | 56.82 (41.20–72.44) | 9 (37.50) | 68.33 (37.51–99.15) | 13 (61.90) | 48.85 (30.41–67.28) | |||
| Gender | |||||||||
| Males, n (%) | 20 (44.44) | 65.15 (47.57–82.73) | 0.4147 | 12 (50) | 78.17 (53.11–103.20) | 0.1925 | 8 (38.09) | 45.63 (24.14–67.11) | 0.2401 |
| Females, n (%) | 25 (55.55) | 64.40 (50.67–78.13) | 12 (50) | 69.75 (49.10–90.40) | 13 (61.90) | 59.46 (38.61–80.31) | |||
| Comorbidities | |||||||||
| Yes, n (%) | 13 (28.88) | 54.08 (31.67–76.48) | 0.6441 | 6 (25) | 64.00 (13.37– | 0.7702 | 7 (33.33) | 45.57 (22.43–68.71) | 0.2386 |
| No, n (%) | 32 (71.11) | 69.06 (56.98–81.14) | 18 (75) | 114.6) 77.28 (61.69–92.87) | 14 (66.66) | 58.50 (38.68–78.32) | |||
| Weight loss | |||||||||
| <10 kg, n (%) | 18 (40) | 65.33 (45.89–84.78) | 0.6698 | 9 (37.5) | 70.44 (38.73–102.20) | 0.8376 | 9 (42.85) | 60.22 (30.57–89.88) | 0.2239 |
| >10 kg, n (%) | 27 (60) | 64.33 (51.50–77.17) | 15 (62.5) | 76.07 (57.73–94.41) | 12 (57.14) | 49.67 (33.21–66.12) | |||
| ODI (mo) | |||||||||
| <24 mo, n (%) | 26 (57.77) | 43.58 (34.03–53.12) | < 0.0001 | 11 (45.83) | 48.64 (30.99–66.28) | 0.0010 | 15 (71.42) | 39.87 (27.87–51.86) | 0.0007 |
| >24 mo, n (%) | 19 (42.22) | 93.98 (81.31–106.10) | 13 (54.16) | 95.38 (78.63–112.1) | 6 (28.57) | 90.00 (66.44–113.60) | |||
| PEG | |||||||||
| Yes, n (%) | 31 (68.88) | 63.52 (50.63–76.40) | 0.7315 | 17 (79.83) | 69.35 (51.33–87.38) | 0.4801 | 14 (66.66) | 56.43 (36.13–76.73) | 0.3952 |
| No, n (%) | 14 (31.11) | 67.43 (47.04–87.82) | 7 (29.16) | 85.14 (50.87–119.40) | 7 (33.33) | 49.71 (27.13–72.30) | |||
| OGI (mo) | (n = 31) | (n = 17) | (n = 14) | ||||||
| <18 mo, n (%) | 16 (51.61) | 42.38 (29.69–55.06) | 0.0002 | 9 (52.94) | 53.78 (35.69–71.86) | 0.0286 | 7 (50) | 27.71 (13.60–41.83) | 0.0006 |
| >18 mo, n (%) | 15 (48.38) | 86.07 (68.72–103.40) | 8 (47.05) | 86.88 (54.34–119.40) | 7 (50) | 85.14 (64.03–106.30) | |||
| MV | |||||||||
| Yes, n (%) | 32 (71.11) | 56.53 (44.75–68.32) | 0.0256 | 18 (75) | 63.28 (46.74–79.81) | 0.0273 | 14 (66.66) | 47.86 (29.99–65.73) | 0.2478 |
| No, n (%) | 13 (28.88) | 84.92 (65.18–104.7) | 6 (25) | 106.0 (84.31–127.70) | 7 (33.33) | 66.86 (38.30–95.41) | |||
| OMVI (mo) | (n = 32) | (n = 18) | (n = 14) | ||||||
| <24 mo, n (%) | 16 (50) | 45.06 (28.34–61.79) | 0.0283 | 8 (44.44) | 50.88 (28.31–73.44) | 0.0953 | 8 (57.14) | 39.25 (9.04–69.46) | 0.3413 |
| >24 mo, n (%) | 61 (50) | 68.00 (51.64–84.36) | 10 (55.55) | 73.20 (47.65–98.75) | 6 (42.85) | 59.33 (38.70–79.97) | |||
| Total cholesterol at onset | (n = 26) | 0.0271 | (n = 15) | 0.0496 | (n = 11) | 0.0860 | |||
| < 4.63 mmol/L, n (%) | 14 (53.84) | 46.64 (31.14–62.15) | 8 (53.33) | 55.88 (30.23–81.52) | 6 (54.54) | 34.44 (18.11–50.56) | |||
| >4.63 mmol/L, n (%) | 12 (46.15) | 77.33 (52.28–102.40) | 7 (46.66) | 91.43 (53.86–129.0) | 5 (45.45) | 57.60 (19.03–96.17) | |||
Kg kilograms, mo months, mmol/L millimoles per liter, MV mechanical ventilation, ODI onset to diagnosis interval, OGI onset to gastrostomy interval, OMVI onset to me chanical ventilation interval, PEG percutaneous endoscopic gastrostomy, 95% CI 95% confidence interval