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. 2019 Oct 29;19:69. doi: 10.1186/s40644-019-0253-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — A 56-year-old woman with suspected primary benign bone tumors of the lumbar vertebra. a Preoperative axial CT image demonstrates osteolytic bone destruction in the fifth lumbar vertebra (yellow arrow). b-c: The intraprocedural axial CT image (using bone windows) shows that the biopsy needle is inserted into the bone lesion (yellow arrow). The histopathologic biopsy results (d: hematoxylin and eosin, original magnification 40×, e: hematoxylin and eosin, original magnification 100×) diagnosed the bone lesion as Langerhans cell histiocytosis. Immunohistochemistry showed that the monocyte-like cells were S ≤ 100 (+), CD1a (+), Langerin (+), CD68 (KP1) (−), CD163 (+), CK (−), and LCA (+); the positive rate of Ki-67 was approximately 10%, and acid fast staining was negative. Finally, the surgical histopathology results (f: hematoxylin and eosin, original magnification 40×) of the bone lesion confirmed the diagnosis of Langerhans cell histiocytosis. Immunohistochemistry showed that the cells were CD1a (+), S ≤ 100 (+), Langerin (+), CD68 (KP1) (weak +), and Ki-67 (Li 20%)