Table 1.

Study descriptions and detailed overview of investigated outcome and exposure variables from Fig. 1

1. DPS study	Exposure		A	C	Outcome		A	C
Assessing the relationship between typical risk factors and the severity of Dupuytren’s contracture N = 411
	Comorbidities	Epilepsy Diabetes mellitus	X	–	Classifications	Iselin	–	X
	Lifestyle	Alcohol Smoking	X	–
	Demography	Sex	X	–	Classifications	Iselin at initial or recurrent diagnosis of Dupuytren’s contracture	–	X
					Demography	Mean age at initial or recurrent diagnosis of Dupuytren’s contracture	X	–
	Classifications	Iselin (stage of Dupuytren’s contracture)	–	X	Complications	Postoperative Intraoperative	X	X
2. DG study	Exposure		A	C	Outcome		A	C
Perforation numbers after endoscopic esophageal balloon dilatation and bougination N = 423	Perforation	Perforation No Perforation	X	–	Length of hospital stay		X	–
3. DRO study	Exposure		A	C/R	Outcome		A	C/R
Comparison of two radiochemotherapies protocols in locally advanced pancreatic cancer N = 13	Radiotherapy Chemotherapy	Radiotherapy + Gemcitabine and cisplatin	X	X	Classifications	Common toxicity criteria	–	–
		Radiotherapy + 5-Fluororuacil and mitomycin C	–	–	Death		X	–
	Additive chemotherapy		X	X	Death		X	–

“X” = available, “-” = unavailable, A: Administrative data (structured data), C: Clinical data (structured and unstructured data), R: Registry data (structured data)