Table 2.

Multivariate Cox regression analysis for the prediction of 28-day mortality upon ED presentation and after 72 h of hospitalisation

Biomarker or clinical score	Patients (N)	Number of events (N)	LR χ2	p value	HR [95% CI]
28-day mortality prediction upon ED presentation
MR-proADM	684	30	53.1	< 0.001	3.8 [2.2 – 6.5]
PCT	684	30	38.2	< 0.001	1.7 [1.1 – 2.5]
Lactate	533	30	34.8	< 0.001	1.5 [1.1 – 2.1]
CRP	646	28	29.0	< 0.001	0.9 [0.6 – 1.4]
SOFA	684	30	53.7	< 0.001	3.2 [2.1 – 5.0]
qSOFA	684	30	46.5	< 0.001	2.3 [1.6 – 3.5]
NEWS	684	30	42.2	< 0.001	2.0 [1.3 – 2.9]
CRB-65	684	30	39.8	< 0.001	1.5 [1.1 – 2.0]
SIRS	684	30	35.4	< 0.001	1.4 [1.0 – 1.9]
28-day mortality prediction after 72 h of hospitalisation
MR-proADM	375	25	36.6	< 0.001	3.0 [1.8 – 4.9]
PCT	370	25	26.2	< 0.001	1.6 [1.1 – 2.4]
Lactate	266	24	20.1	< 0.01	1.0 [0.7 – 1.5]
CRP	281	20	17.6	< 0.001	0.8 [0.4 – 1.3]
SOFA	375	25	33.7	< 0.001	2.0 [1.4 – 2.7]
qSOFA	376	25	22.5	< 0.001	1.4 [0.8 – 2.3]
NEWS	376	25	26.5	< 0.001	1.6 [1.1 – 2.3]
CRB-65	376	25	22.3	< 0.001	1.3 [0.8 – 2.2]
SIRS	376	25	24.9	< 0.001	1.5 [1.0 – 2.3]

Multivariate analysis was adjusted by age, diabetes, malignancy, and liver and renal disease variables. CI confidence interval, CRB-65 severity score for community-acquired pneumonia, CRP C-reactive protein, DF degrees of freedom, LR likelihood ratio, MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score, HR hazard ratio, PCT procalcitonin, qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome, SOFA Sequential Organ Failure Assessment