Table 3.

Patient subgroups stratified by NEWS and MR-proADM

Patient subgroups	Patient populations stratified by NEWS and MR-proADM
	MR-proADM (nmol/L)	NEWS (points)	MR-proADM (nmol/L)	NEWS (points)	MR-proADM (nmol/L)	NEWS (points)	MR-proADM (nmol/L)	NEWS (points)
	< 1.77	< 5	≥ 1.77	< 5	< 1.77	≥ 5	≥ 1.77	≥ 5
Population, N (%)	425 (62.1%)		74 (10.8%)		100 (14.6%)		85 (12.8%)
Antibiotic administration, N (%)	266 (62.6%)		63 (85.1%)		94 (94.0%)		82 (96.5%)
Time to antibiotic administration (min) (median [Q1–Q4])	180 [90 – 342]		205.5 [111 – 300]		210 [142 – 315]		180 [100 – 300]
Antibiotic administration < 180 min, N (%)	108 (40.6%)		26 (41.3%)		30 (31.9%)		33 (40.2%)
i.v. to oral antibiotic change (days) (median [Q1–Q4])	1.5 [1 – 4]		4.0 [0 – 6.75]		4 [2 – 6]		3.5 [0 – 4.5]
Hospitalisation, N (%)	260 (61.2%)		63 (85.1%)		93 (93.0%)		82 (96.5%)
Length of hospitalisation (days) (median [Q1–Q4])	1 [0 – 5]		6 [3 – 11]		7 [4 – 10]		7 [4 – 13]
Infection-related readmission, N (%)	25 (5.9%)		14 (18.9%)		3 (3.0%)		9 (10.6%)
ICU admission, N (%)	7 (1.6%)		6 (8.1%)		2 (2.0%)		8 (9.4%)
Time to ICU admission (days) (median [Q1–Q4])	13 [2 – 20]		1.5 [1 – 5]		9.5 [4.75 – 14.25]		0 [0 – 0]
Number of immediate ICU admissions, N (%)	0 (0.0%)		0 (0.0%)		0 (0.0%)		7 (30.4%)
Number of delayed ICU admissions, N (%)	2 (8.7%)		5 (21.7%)		1 (4.3%)		0 (0.0%)
Number of late ICU admissions, N (%)	5 (21.7%)		1 (4.3%)		1 (4.3%)		1 (4.3%)
Infection-related 28-day mortality, N (%)	0 (0.0%)		10 (13.5%)		6 (6.0%)		14 (16.5%)
Hospital mortality, N (%)	1 (0.2%)		10 (13.5%)		9 (9.0%)		15 (17.6%)
Disease progression, N (%)	21 (4.9%)		22 (29.7%)		12 (12.0%)		24 (28.2%)

Number of immediate, delayed, or late ICU admissions are expressed as a percentage of the total number of ICU admissions. ICU intensive care unit, i.v. intravenous, MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score