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. 2019 Oct 23;13:55. doi: 10.3389/fnsys.2019.00055

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Copyright © 2019 Thomas, Guercio, Drudik and de Villers-Sidani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sound exposed rats demonstrate a frequency-specific enhancement in PPI. (A) A schematic drawing of the behavioral protocol. Testing takes place in the presence of a continuous 65 dB SPL background noise. A 20 ms tone pip (3.5 or 7 kHz, 75 dB SPL) preceding the startle sound (40 ms white noise burst, 120 dB SPL) reduces the magnitude of the acoustic startle response. (B) Percent PPI (Top), baseline startle response (Bottom Left), and comparison of startle response between Baseline (B) and Prepulse (P) trials (Bottom Right) when the prepulse is a 7 kHz tone. Lines connect responses from the same animal. (C) Percent PPI (Top) and comparison of startle response between Baseline (B) and Prepulse (P) trials (Bottom) when the prepulse is a 3.5 kHz tone. Lines connect responses from the same animal. Note that the same baseline startle values were used for computing PPI in (B,C). *p < 0.05, ns, not significant. N rats per group: 12 Naive, 12 Exposed. PPI, Prepulse Inhibition of the acoustic startle response.