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. 2019 Oct 29;10(5):e02174-19. doi: 10.1128/mBio.02174-19

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FIG 5 — Role of CTH in polyamine production. (a and b) RAW 264.7 macrophages (a) or BMmacs (b) were infected or not with H. pylori for 24 h. Cells were washed, and fresh medium containing antibiotics with or without AOAA or DZNeP was added. Polyamine concentrations were measured in macrophages after 24 h. *, P < 0.05; **, P < 0.01; ****, P < 0.0001 (compared to uninfected cells); §, P < 0.05; §§, P < 0.01; §§§§, P < 0.0001 (versus H. pylori-infected macrophages) (n = 3). (c) RAW 264.7 macrophages were transfected with LmnA, Cth, or Cbs siRNA and then infected with H. pylori for 24 h. Cells were washed, and fresh medium containing antibiotics was added. Polyamine concentrations were measured in macrophage lysates after 24 h. *, P < 0.05; **, P < 0.01 (versus infected cells with LmnA siRNA); §§, P < 0.01 (compared to cells transfected with Cth siRNA) (n = 4). (d) Intracellular concentrations of dcSAM were determined in RAW 264.7 macrophages stimulated as described above for panels a and c.