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. 2019 Jul 16;33(3):300–303. doi: 10.1016/j.sjopt.2019.07.001

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Right upper eyelid excisional biopsy stained with hematoxylin-phloxine and saffron. (A) Low powered magnification (original magnification 10×) image illustrating a predominant homogenous population of pale amphophilic cells with interspersed fibrous connective tissue and areas of pale necrosis consistent with tissue destruction. Complete effacement of the normal eyelid tissue is evident, features not-suggestive of a chalazion. (B) High powered magnification (original magnification 40×) image illustrating the homogenous population of the eyelid lesion consisting of discohesive, large nuclear cells with ample eosinophilic cytoplasmic and very prominent nucleoli. Nuclear atypica is evident throughout the image. Mitotic figures and nuclear groves can be seen. Lipogranulomas were absent. (C) Higher powered magnification (original magnification 20×) image of the eyelid lesion illustrating perineural invasion. (D) Low powered magnification (original magnification 10×) image of the eyelid lesion illustrating skeletal muscle invasion.