Figure 2.

Pten-deficient telocytes and Apc^Min/+mutation increases adenoma multiplicity but not epithelial transformation in mice. Total (A) colonic polyps and (B) adenomas were counted from 75-day-old Apc^Min/+, Pten^ΔFoxl1+, and Pten^ΔFoxl1+;Apc^Min/+ mice. (C) Histologic assessment showed an increase of adenoma multiplicity in Pten^ΔFoxl1+;Apc^Min/+ when compared with Apc^Min/+ colons (N = 6 and 5, respectively). Asterisks indicate adenomatous polyps. (D) All Apc^Min/+ polyps were assessed histologically as adenomas. (D) Adenomas, (E) lymphoid aggregates, and (F) a mixed adenoma were found in Pten^ΔFoxl1+;Apc^Min/+ colons. Data are expressed as means ± SEM. Mann–Whitney U test: **P ≤ .01, ***P ≤ .001, and ****P ≤ .0001. Scale bars: (A) 1 mm, (D–F) 500 μm.