FIG 3.
IFN-λ cytokines limit MNoV infection. MNoV.CR6 genome copies were detected by RT-qPCR in stool at day 7 postinfection (A) and in colon at day 14 postinfection (B) in WT, Ifnl2−/− Ifnl3−/−, and Ifnlr1−/− mice after peroral inoculation with 106 PFU. (C and D) MNoV.CR6 viral copies in stool (C) and colon (D) of littermate WT, Ifnl2+/− Ifnl3+/−, and Ifnl2−/− Ifnl3−/− mice 14 days postinfection with 106 PFU. (E) MNoV copies detected in WT and Ifnl2−/− Ifnl3−/− mice 14 days postinoculation with 106 PFU MNoV.CR6NS1−CW3. Data were combined from results from at least two experiments performed with 3 to 14 mice per group per experiment. MNoV.CR6 and MNoV.CR6NS1−CW3 infection data were analyzed by Kruskal-Wallis test with Dunn’s multiple-comparison test and Mann-Whitney test, respectively.