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Breast cancer proteases that inactivate reovirus are metalloproteases. (A and B) Reovirus was treated with 1× T.E.E. (+) in the presence of various protease inhibitors (as indicated) and analyzed by Western blotting as described for Fig. 1 (representative of two independent experiments) (A) or by plaque titration on L929 cells as described for Fig. 2 (two independent experiments) (B).
