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. 2019 Aug 30;5(5):503–510. doi: 10.1002/osp4.360

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© 2019 The Authors Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Baseline fasting fibroblast growth factor 21 (FGF21) levels before and after the study period for men and women. Women had significantly higher baseline FGF21 levels and decreased baseline FGF21 levels after 2 weeks of fructose exposure (p = 0.04). (B) Fructose‐stimulated FGF21 levels before and after the study period for men and women. Women had significantly higher FGF21 levels than men at both time points (^* p < 0.008). (C) The fold change of FGF21 following 75 g of oral fructose tolerance test (OFTT) was significantly elevated in women after fructose intervention (^* p < 0.05; ^** p < 0.01).