Table 2.

Sex differences in the effects of high‐fructose exposure (men: n = 8; women: n = 11)

	Week 0			Week 2			Within sex
	Male	Female	p	Male	Female	p	p (male)	p (female)
Fasting total FGF21 (pg ml−1)	85.70 ± 29.43	211.37 ± 40.86	0.03*	79.17 ± 28.98	106.48 ± 18.04	0.42	0.39	0.02*
Stimulated total FGF21 (pg ml−1)	225.26 ± 75.76	661.33 ± 115.41	0.008*	291.05 ± 88.15	636.57 ± 64.66	0.005*	0.24	0.86
Fold change of total FGF21	2.79 ± 0.53	3.48 ± 0.35	0.28	4.41 ± 0.86	7.64 ± 1.22	0.05	0.10	0.001*
Fasting intact FGF21 (pg ml−1)	40.57 ± 22.54	83.98 ± 22.28	0.27	36.09 ± 17.71	37.74 ± 10.05	0.93	0.72	0.03*
Stimulated intact FGF21 (pg ml−1)	53.52 ± 25.26	227.95 ± 53.61	0.03*	143.21 ± 65.12	278.36 ± 34.39	0.06	0.08	0.42
Fold change of intact FGF21 (pg ml−1)	0.84 ± 0.68	4.62 ± 1.19	0.19	2.83 ± 0.95	6.65 ± 1.65	0.14	0.08	0.04*
Baseline ratio intact: total FGF21	0.22 ± 0.09	0.33 ± 0.06	0.35	0.28 ± 0.08	0.28 ± 0.08	0.94	0.75	0.50
Stimulated ratio intact: total FGF21	0.28 ± 0.11	0.35 ± 0.06	0.55	0.38 ± 0.08	0.46 ± 0.07	0.50	0.21	0.16

Values are average ± standard error. p values <0.05 are considered significant.

FGF21, fibroblast growth factor 21.

^*  = p < 0.05