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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Acta Biomater. 2019 Jun 12;94:183–194. doi: 10.1016/j.actbio.2019.05.063

Fig. 5.

Fig. 5.

Neotissue formation and remodeling in arterial and venous TEVGs. Histologic and immunohistochemical evaluation of explanted arterial grafts at 6 (A, F, K, P) and 12 (B, G, L, Q) weeks post implantation and explanted venous grafts at 6 (C, H, M, R), 12 (D, I, N, S), and 24 (E, J, O, T) weeks post implantation. MT (A-E) identified extracellular matrix deposition, vWF (F-J) demonstrated the development of a confluent endothelial cell monolayer by 12 weeks in both groups, F4/80 (K-O) identified macrophage infiltration and proliferation and MMP-2 (P-T) evidenced ECM turnover and active tissue remodeling. All photomicrographs at 40× magnification. Scale bar = 50μm.