Fig. 7.

Compound activity mapping workflow. (A) Network analysis of the full chemical space of the tested actinobacterial extracts. Light blue nodes represent extracts connected to all m/z features (red), illustrating the immense chemical complexity of the extract library. (B) Activity histograms and cluster scores for all m/z features. (C) Compound activity map, displaying only extracts and m/z features predicted to be responsible for consistent phenotypes of interest. (D) Close up of a specific bioactive cluster, belonging to the staurosporine natural product family. This figure is reprinted with permission from Kurita et al. 2015.¹⁴⁷