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. Author manuscript; available in PMC: 2019 Oct 30.
Published in final edited form as: Nat Prod Rep. 2019 Jun 19;36(6):869–888. doi: 10.1039/c9np00011a

Table 1.

Recommended fractional inhibitory concentration (∑FIC) indices for assigning combination effects

Combination effect ∑FIC range
Synergy ∑FIC ≤ 0.5
Additivity 0.5 < ∑FIC ≤ 1.0
Indifference 1.0 < ∑FIC ≤ 4.0
Antagonism 4.0 < ∑FIC