A, Associations for APOE ɛ4 with regional tau. B, tau-mediated metabolic dysfunction modeled as the fluorodeoxyglucose (FDG) to tau ratio. Associations include global amyloid burden as a covariate in addition to age, sex, and an index score of cerebrovascular disease risk, which were included in Figure 1. Light blue boxes indicate uncorrected P < .05; dark blue boxes, uncorrected P ≥ .05; shading, contiguous regions; ant, anterior; inf, inferior; mid, middle; oper, operculum; orb, orbital; sup, superior; and tri, triangularis.