Table 2. Factors Accounting for the Variance in Tau Burden and FDG Metabolism in Key Alzheimer Disease Regions via Stepwise Regressions.

Factor	β (95% CI)	Unique Adjusted R2	P Value
Tau Models
Entorhinal cortex tau
Global amyloid	0.34 (0.28 to 0.39)	0.32	<.001
CMC scorea	0.01 (0.001 to 0.02)	0.01	.03
Inferior temporal cortex tau
Global amyloid	0.20 (0.15 to 0.24)	0.24	<.001
Age	0.001 (0.000 to 0.003)	0.01	.049
Posterior cingulate cortex tau
Global amyloid	0.14 (0.10 to 0.18)	0.11	<.001
FDG Models
Entorhinal cortex FDG
Entorhinal cortex tau	−0.15 (−0.21 to −0.09)	0.18	<.001
Age	−0.002 (−0.003 to −0.001)	0.06	<.001
Global amyloid	−0.05 (−0.09 to −0.01)	0.02	.01
Inferior temporal cortex FDG
Global amyloid	−0.13 (−0.18 to −0.09)	0.13	<.001
Age	−0.002 (−0.004 to −0.001)	0.04	.005
Sex (male)	−0.03 (−0.05 to −0.01)	0.03	.002
CMC scorea	−0.007 (−0.01 to 0.00)	0.01	.04
Education	0.004 (0.00 to 0.008)	0.01	.04
Posterior cingulate cortex FDG
Global amyloid	−0.21 (−0.29 to −0.13)	0.12	<.001
Sex (male)	−0.08 (−0.12 to −0.05)	0.08	<.001
CMC scorea	−0.02 (−0.04 to −0.01)	0.06	<.001
Age	−0.004 (−0.006 to −0.001)	0.02	.004

Abbreviations: CMC, cardiovascular and metabolic conditions; FDG, fluorodeoxyglucose.

^aIndex score of cerebrovascular disease risk.