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Plasma and heart concentrations of Cpd 38 after 5-min i.v. administration in anesthetized male Hartley guinea pigs (values are mean ± SD with n = 6 per group).
| Dose | Sampling time | Total plasma concentration | Heart concentration | ||
|---|---|---|---|---|---|
| mg/kg | min | μg/mL | μM | μg/g | μM |
| 10 | 10 | 4.66 ± 1.35 | 12.8 | Not taken | Not taken |
| 30 | 2.57 ± 0.533 | 7.1 | 6.01 ± 0.964 | 16.6 | |
