Value of the Data •Data point out currently understudied epidemiological sex differences in human adolescent populations as it relates to liver effects associated with exposure to perfluoroalkyl acids. •By highlighting differences between male and female adolescents in markers of liver function, data can be useful to researchers focusing on the study of pediatric liver disease. •Data provide a basis for further epidemiological analysis of sex differences in different human populations exposed to perfluoroalkyl acids.