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Mechanism of PAR4/P2Y12 mediated αIIbβ3 and Rap1 activation and P-selectin expression. Schematic model of platelet activation upon prasugrel-mediated reduction in stent thrombosis through inhibition of dual thrombin receptors. Fast onset of inhibition of ADP signaling with the enhanced P2Y12 inhibitor prasugrel uncovered a new role for P2Y12/PAR4 in formation of more stable, growing platelet aggregates which contribute to both enhanced hemostasis and thrombosis.
