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(A) RRMS in relapse versus RRMS in remission and (b) all patients with MS in relapse versus all MS. (a) CSF NfL levels are higher in RRMS in relapse than in remission; (b) when progressive and patients with RRMS are combined as ‘all patients’, CSF NfL levels remain higher in relapse patients than remission patients. CSF, cerebrospinal fluid; MS, multiple sclerosis; NfL, neurofilament light chain; RRMS, relapsing remitting MS; SMD, standard mean deviation.
