Table 2.
List of relevant antidiarrheal compounds.
| Type | Drug compound | References |
|---|---|---|
| Enteric nervous system blocker | Dicyclomine, hyoscyamine, alosetron, clonidine, loperamide, diphenoxylate, and racecadotril | Cheng1 and Farthing30 |
| Enterotoxin-induced secretory blocker | Atropine/hyocyamine, tetrodotoxin, hexamethonium, lignocaine/lidocaine, and igmesine | Farthing30 and Turvill et al31 |
| Tight junction compounds | Corticosteriods, mercaptopurine (6-MP), and inflixamab | Cheng1 |
| Proabsorptive and other antisecretory agents | Somastatin, octreotide, gallic acid, d-galacturonic acid, nicotinic acid, indomethacin, berberine, and amphotericin B | Farthing30 and Edelman32 |
| Pathogen box antidiarrheal agents | MMV002817 (iodoquinol), MMV687800 (clofazimine), MMV688978 (auranofin), MMV688991 (nitazoxanide), MMV010576, MMV028694, and MMV676501 | Hennessey et al19 |
| T3SS inhibitors | Lactoferrin, phenoxyacetamide, 2,2′-thiobis-(4-methylphenol), 8-hydroxyquinoline, pseudoceramides, (-)-hopeaphenol, p-coumaric acid, Benzoic acid, 4-methoxy-cinnamic acid, caminosides A, caminosides B, guadinomine B, cytospore B, fusaric acid, thiazolidinone, N-hydroxybenximidazoles, and regacin | Yang et al,12 Charro and Mota,17 and Gomez et al33 |
| Bacterial enzyme/receptor inhibitors | Zhankuic acid A, N-methyl-piperazine-Phe-homoPhe-vinylsulfone phenyl (K11777), genistein, and isorhamnetin | Chen et al,15 Ndao et al,16 Sparks et al,34 and Sabbagh and Berakdar,35 |
| Replication initiation (virulence cascade) inhibitors | Virstatin, toxtazin A, toxtazin B, toxtazin B′, vibrepin (3-(3,4-dichlorophenyl)cyclopropane-1,1,2,2-tetracarbonitrile), N-acylcyclopentylamine, N-coeleneterazine (DB04118), and N-(1,4-dihydro-5H-tetrazol-5-ylidene)-9-oxo-9H-xanthene-2-sulfonamide (DB04698) | Anthouard and DiRita,10 Yamaichi et al,11 Mondal et al,36 and Wang et al37 |