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. 2019 Oct 30;39(44):8762–8777. doi: 10.1523/JNEUROSCI.0708-19.2019

Figure 3.

Figure 3.

Effects of intra-vHipp drug treatments on rewarding and aversive memory formation. a, Photomicrograph demonstrating a representative vHipp microinfusion site. b, Effects of intra-vHipp VEH, THC (10 and 100 ng), CBD (10 and 100 ng), THC+CBD (100 ng+100 ng), THC+U0126 (100 ng+1 μg), and THC+CBD+EPA (100 ng+100 ng+1 mm) on percentage of time freezing to contextual, and (c) olfactory-associative CS+ and CS− cues, (d) percentage of time spent in morphine and saline-paired contexts during subreward threshold morphine (0.05 mg/kg, i.p.) CPP testing, (e) sucrose preference, and (f) water intake during sucrose preference testing. Intra-vHipp drug infusion occurred before each conditioning session. n = 7–11 rats, one-way, or mixed-measures ANOVAs; *p < 0.05, **p < 0.01. Error bars indicate SEM.