Figure 5.

Differential roles for dBtk in latency and habituation in α/β and α′/β′ MB neurons. Habituation indices quantifying the difference in footshock avoidance following exposure to the indicated number of stimuli from that of same genotype naive flies are shown as the mean ± SEM for the indicated number of repetitions (n). Filled circles represent the mean performance of animals with abrogated dBtk; whole open squares, the respective controls. Asterisks indicate significant differences from controls as detailed in the text. A, Adult-limited pan-MB expression of btk^Ri-1 (IN) yields premature habituation after 6 and 10 stimuli and failed habituation after 15 shocks compared to in-genotype controls of siblings with the transgene silent (UN). n > 18 for all groups. B, The complementary experiment of adult-limited pan-MB expression of UAS-btk^s rescued (IN) the premature habituation after 6 and 10 stimuli, as well as the habituation deficit after 15 footshocks compared to siblings not expressing the transgene (UN). n ≥ 12 for all groups. C, Adult-limited expression of btk^Ri-1in α/β MB neurons (IN) recapitulates the premature habituation after 6 and 10 shocks but not the failed habituation after 15 stimuli, compared to siblings not expressing the transgene (UN). n ≥ 10 for all groups. D, Adult-limited expression of btk^Ri-1in α′/β′ MB neurons (IN) recapitulates the failed habituation to 15 footshocks, but not the premature habituation to 6 or 10 stimuli compared to siblings not expressing the transgene (UN). n ≥ 11 for all groups.