Table 4.
Nonreplication of each of the main findings from Pinel et al. (2012) in multiple independent samples and in a combined analysis using F tests to assess genotype associations with ROI activations
| GENESNP | Pinel et al. (2012) effects | Subsample | p-value | F-test value |
|---|---|---|---|---|
| FOXP2rs6980093 | AA > AG > GG | MOUS visual | 0.16 | F(1,106) = 1.85 |
| Left inferior frontal gyrus activation | MOUS auditory | 0.36 | F(1,107) = 1.05 | |
| Visual and auditory | EvLab visual | 0.66 | F(1,201) = 0.41 | |
| Combined | 0.20 | F(2,416) = 1.60 | ||
| FOXP2rs7784315 | TC > TT | MOUS visual | 0.85 | F(1,104) = 0.37 |
| Left precentral gyrus activation | EvLab visual | 0.91 | F(1,198) = 0.01 | |
| Visual only | Combined | 0.97 | F(1,304) = 0.00 | |
| KIAA0319…rs17243157 | CC > TC | MOUS visual | 0.56 | F(1,105) = 0.34 |
| Superior temporal sulcus functional asymmetry | MOUS auditory | 0.21 | F(1,107) = 1.58 | |
| Visual and auditory | EvLab visual | 0.48 | F(1,197) = 0.50 | |
| Combined | 0.30 | F(1,411) = 1.07 |
For rs6980093, we tested the three allelic groups, whereas for rs7784315 and rs17243157, we compared major allele homozygotes with heterozygotes, as the homozygous minor allele groups were too small for a meaningful comparison (see main text).