Figure 6.

Proposed sequence and interactions of HC-SWRs with GE in NC and thalamus. A1. NC-TBs appear to arise spontaneously in widespread cortical areas and may trigger NC-DS (A2). TBs modulate cortical firing before HC-SWRs, which would reflect earlier learned networks, and may be projected to the HC before the SWRs (A3). Thalamic hyperpolarization from converging NC-DS (A4) would enable h and T currents, thus triggering the thalamic-SS (A5). NC-DSs converging on the HC may contribute to SWR occurrence (A6). B, The HC-SWRs follows, and if humans are similar to other mammals, marks the wide NC distribution of recent event replay. C1. HC-SWR output arrives at the NC DS→US transition, when the thalamic SS is driving the NC-SS (C2). Thus, our results suggest how GE may coordinate, sequence, and modulate information transfer between NC and HC to enable memory consolidation. While consistent with current and previous observations (Mak-McCully et al., 2017; Gonzalez et al., 2018), these data are correlational and require mechanistic studies in humans and animals for confirmation.