Table 4.
Summary of four-way ANOVA comparing associations between HC-SWR and NC-GEa
| Source | F (df) | p value | Post hoc analysis (if any) and corresponding p value (Tukey's range test) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Main effect | GE | 136.9 (3,27) | 1.93 × 10−16 | TB versus SS | TB versus DS | TB versus US | SS versus DS | SS versus US | DS versus US | |||||
| NS | 3.774 × 10−9 | 3.774 × 10−9 | 3.773 × 10−9 | 3.773 × 10−9 | NS | |||||||||
| Stage | 61.4 (1,27) | 2.01 × 10−8 | NA | |||||||||||
| AP | 41.5 (1,27) | 6.72 × 10−7 | NA | |||||||||||
| ROI | 10.6 (9,27) | 8.47 × 10−7 | LT | CG | OF | PF | PC | MTO | MOP | IS | LP | LO | ||
| CG versus | 0.0099 | NA | NS | NS | 0.0235 | 0.0005 | 0.0106 | 0.0171 | 0.0007 | 3.211 × 10−7 | ||||
| LO versus | 0.0062 | 3.211 × 10−7 | 1.880 × 10−5 | 1.958 × 10−5 | 0.0025 | NS | 0.0058 | 0.0035 | NS | NA | ||||
| Two-way interaction | GE × stage | 1.2 (3,27) | 0.3180 | NA | ||||||||||
| GE × AP | 4.6 (3,27) | 0.0103 | aHC versus pHC | TB | DS | SS | US | |||||||
| 0.0005 | 0.0049 | 1.0000 | 0.0564 | |||||||||||
| GE × ROI | 3.3 (27,27) | 0.0013 | TB: CG > PC (p = 0.0373), MTO (0.0184), MOP (0.0139), LO (0.0030); SS: OF > LT (0.0089), PC (0.0082), IS (0.0002), LO (0.0036); DS: CG > LO (0.0277); US: CG > LO (0.0121). | |||||||||||
| Stage × AP | 8.8 (1,27) | 0.0062 | aHC versus pHC | N2 | N3 | |||||||||
| 2.283 × 10−6 | 0.0910 | |||||||||||||
| Stage × ROI | 6.8 (9,27) | 4.93 × 10−5 | N2 versus N3 | LT | CG | OF | PF | PC | MTO | MOP | IS | LP | LO | |
| NS | NS | 3.528 × 10−6 | NS | NS | NS | NS | 0.0051 | NS | NS | |||||
| AP × ROI | 2.9 (9,27) | 0.0143 | aHC versus pHC | LT | CG | OF | PF | PC | MTO | MOP | IS | LP | LO | |
| NS | NS | NS | 0.0103 | NS | NS | NS | NS | NS | NS | |||||
| Three-way interaction | GE × stage × AP | 0.1 (3,27) | 0.9380 | NA | ||||||||||
| GE × stage × ROI | 1.3 (27,27) | 0.2264 | NA | |||||||||||
| GE × AP × ROI | 1.2 (27,27) | 0.3254 | NA | |||||||||||
| Stage × AP × ROI | 3.0 (9,27) | 0.0140 | PF: N2 pHC > N3 aHC (p = 0.0328) OF: N2 pHC > N2 aHC, N3 aHC, N3 pHC (p = 0.0003, 7.559 × 10−6, 4.582 × 10−6) | |||||||||||
aFor each HC-NC electrode pair and sleep stage (N2 vs N3), the significance of the NC-GE occurrence times relative to the ripple center was determined (see Fig. 1; Materials and Methods). We then tallied the proportion of significant channel pairs according to their HC location (aHC, pHC), NC location (see Extended Data Table 3-1; and Fig. 5A), and GE type (TB, DS, SS, US). These proportions were then entered into ANOVA. LO, Lateral occipital; LT, lateral temporal; CG, cingulate; OF, orbitofrontal; PF, prefrontal; PC, paracentral; MTO, medial temporo-occipital; MOP, medial occipitoparietal; IS, insula; LP, lateral parietal; NS, not significant (for post hoc Tukey's range tests, p > 0.1).