Figure 1.

Longitudinal In Vivo PC-CT Imaging of Spontaneous Liver Tumor Dynamics in the Alb-R26^Met Model

(A) Schematic representation of longitudinal in vivo imaging studies that we performed to follow tumor initiation and evolution over time in the Alb-R26^Met mouse model. Three cohorts were used for imaging of untreated mice (1° cohort), mice treated with drug combinations (2° cohort), and mice with a short treatment with drug combinations to perform histological studies (3° cohort).

(B) Example of longitudinal monitoring of liver tumor growth in an Alb-R26^Met mouse (M1) with the PIXSCAN-FLI PC-CT prototype. For this representative mouse, image monitoring was performed at D0, D14, D28, D42, D49, D56, D63, D70, D77, and D84. For each day of monitoring, transversal (top), coronal (left bottom), and sagittal (right bottom) slices are shown. The red arrows indicate tumor already detected at D0. The white arrows at D0 and D42 point to the venae cava. The yellow arrows indicate additional spontaneous tumors detected starting from D42.

See also Figures S1 and S2.