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. 2019 Oct 10;21:84–94. doi: 10.1016/j.isci.2019.10.016

Figure 3.

Figure 3

The Soft Palate Displays Superior Healing Ability Than the Hard Palate

(A) Intact hard and soft palates.

(B–E) (B) A 2-mm full-thickness injury (black dashed circle) was created in the area between the hard and soft palates. The center of the injury was located in the cross point of the middle line and the line along with the posterior ends of third molars. Yellow dashed circle indicates the unhealed part. Mice at age of 3 months were subjected to the injury and then monitored for (C) 3 days, (D) 7 days, and (E) 14 days.

(F-I) Representative Masson trichrome staining showing the healing of hard and soft palates on. (F) PSD1, (G) PSD3, (H) PSD7, and (I) PSD14. The black brackets indicate the injury site. The orange lines indicate the unhealed injury.

(J) Quantification of wound area shown in (B)–(E) (n = 6).

(K) Calculated repair rate between PSD1 and PSD3 (n = 6). Abbreviation: m1, maxillary first molar; m2, maxillary second molar; m3, maxillary third molar; PSD, post-surgery day; in, injury; hp, hard palate; sp, soft palate. Data represent mean ± SD. Scale bars: 200 μm.