Table 1.
Correlations between exosomal MT1-MMP mRNA, CEA, and clinicopathological variables [median (interquartile range)].
| Variables | N | MT1-MMP mRNA | U value | P value | CEA (ng/ml) | U value | P value | |
|---|---|---|---|---|---|---|---|---|
| Gender | Male | 89 | 5.045 (1.862, 8.786) | 1040 | 0.071 | 2.520 (1.725, 4.088) | 1029 | 0.062 |
| Female | 30 | 3.392 (0.229, 6.764) | 1.835 (1.250, 3.220) | |||||
| Age | ≤61 | 61 | 3.647 (1.161, 7.723) | 1540 | 0.223 | 2.310 (1.503, 3.525) | 1587 | 0.333 |
| >61 | 58 | 5.122 (1.820, 8.089) | 2.325 (1.740, 4.480) | |||||
| Cancer location | Antrum | 47 | 4.965 (0.558, 8.873) | 0.922* | 0.817 | 2.420 (1.603, 4.180) | 1.490* | 0.685 |
| Angulus | 23 | 5.037 (1.830, 7.160) | 2.240 (1.575, 3.900) | |||||
| Cardia | 28 | 3.952 (1.471, 7.228) | 2.165 (1.580, 3.170) | |||||
| Body | 21 | 5.045 (2.143, 8.256) | 2.910 (1.743, 4.440) | |||||
| Tumor diameter | ≤3 cm | 56 | 3.671 (0.230, 6.374) | 1184 | 0.002 | 2.210 (1.500, 3.115) | 1368.5 | 0.035 |
| >3 cm | 63 | 6.764 (2.387, 9.279) | 2.780 (1.665, 5.818) | |||||
| Differentiation | Well | 12 | 1.234 (0.096, 3.952) | 8.663* | 0.013 | 2.150 (1.945, 2.210) | 4.146* | 0.126 |
| Moderately | 25 | 5.199 (2.579, 9.291) | 2.860 (1.725, 5.778) | |||||
| Poorly | 82 | 5.066 (1.876, 8.482) | 2.305 (1.510, 3.930) | |||||
| Bormann | I | 19 | 1.748 (0.092, 5.516) | 11.037* | 0.012 | 2.070 (1.475, 2.403) | 5.693* | 0.128 |
| II | 57 | 4.448 (1.573, 7.058) | 2.370 (1.478, 4.088) | |||||
| III | 27 | 6.764 (3.371, 8.775) | 2.910 (1.913, 8.438) | |||||
| IV | 16 | 7.490 (2.776, 9.637) | 2.195 (1.630, 3.040) | |||||
| Invasion depth | T1 | 28 | 1.988 (0.074, 5.066) | 24.385* | <0.001 | 2.115 (1.500, 2.760) | 8.404* | 0.038 |
| T2 | 19 | 2.416 (1.322, 5.599) | 2.620 (1.840, 3.953) | |||||
| T3 | 23 | 5.199 (2.654, 7.588) | 2.060 (1.235, 3.218) | |||||
| T4 | 49 | 7.359 (3.196, 10.540) | 2.920 (1.718, 6.235) | |||||
| Lymphatic metastasis | No | 48 | 2.695 (0.138, 5.005) | 781 | <0.001 | 2.210 (1.535, 3.195) | 1370 | 0.070 |
| Yes | 71 | 7.028 (2.848, 9.391) | 2.620 (1.645, 6.765) | |||||
| Distal metastasis | No | 99 | 3.813 (1.207, 7.160) | 397 | <0.001 | 2.350 (1.595, 3.953) | 941.5 | 0.730 |
| Yes | 20 | 9.150 (6.476, 16.019) | 2.275 (1.585, 6.500) | |||||
| TNM Stage | I | 37 | 2.299 (0.095, 4.843) | 35.69* | <0.001 | 2.120 (1.473, 2.480) | 8.404* | 0.038 |
| II | 29 | 2.973 (1.802, 7.420) | 2.960 (1.785, 4.443) | |||||
| III | 33 | 6.983 (2.999, 9.578) | 2.780 (1.670, 8.343) | |||||
| IV | 20 | 9.150 (6.476,16.019) | 2.275 (1.585, 6.500) | |||||
| Hypertension | No | 89 | 5.088 (1.589, 8.521) | 1213 | 0.455 | 2.240 (1.515, 4.383) | 1268 | 0.682 |
| Yes | 30 | 4.032 (2.185, 7.219) | 2.330 (2.140, 3.170) | |||||
| Fecal occult blood | No | 84 | 4.625 (1.251, 7.801) | 1334 | 0.428 | 2.350 (1.670, 4.455) | 1277 | 0.260 |
| Yes | 35 | 4.965 (2.328, 8.844) | 2.300 (1.300, 3.283) | |||||
*
χ2 value.